A fork of Rural Dictionary
When you yell and scream over everything.
My friend got Jacksepticeye Syndrome after I beat him in a game.
When someone, usually when gaming, yells and screams at their screen. They're normally loud but doesn't have to be to class as jacksepticeye syndrome. Not to be confused with anything about loving jacksepticeye or being a fan.
My friend got jacksepticeye syndrome when I beat him in a game.
Watching so much Jacksepticeye that you unintentionally fall in love with him.
I got a case of the Jacksepticeye syndrome. I mean, look how cute he is! I want to fuck his brains out.