A fork of Rural Dictionary
Despondency related to a lack of marijuana. A play on the phrase "reefer madness," which is originally a 1936 anti-marijuana propaganda film.
Man, last week my mom smoked all my shit, and I'm broke. I had a bad case of reefer sadness.
Depression and/or woe caused by a lack of marijuana.
“Sorry dude, I’ve been feelin that reefer sadness since my plug moved to Portland.”