A fork of Rural Dictionary
Someone who is so unfortunate looking that they are unable to use the video option on Skype.
As Luke had his Skype video call rejected by his girlfriend at 6 a.m. on sunday morning, he realized he had become The Anti-Skype!
A condition that always causes the sufferer to derp in photographs.
After being unable to find a single photo for his Facebook profile in which he did not derp, Damon began to suspect that he had contracted Derpese