A fork of Rural Dictionary
Up-Syndrome is when you have more than 62 chromosomes (basically being a SPED Class in one person), this usually occurs in when a male and a female have reproductive sex over the age of 50.
This kid with Up-Syndrome is CRAZY!!!
A being of such a massive intellect and high IQ that they are completely unable to function in plebian society.
Oliver is such a god at Smash Bros, I wonder if he has up syndrome.
When you're so smart your brain is disfunctional.
Wow that guy has severe up syndrome!
Elaboration of the severity of the condition down syndrome
Up Syndrome: You got down syndrome so bad, you probably got up, left, and right syndrome too
having the disorder that makes you tie one octillion balloons to your house daily
up syndrome isnt the opposite of down syndrome
The condition where genitalia is in a perpetually happy state.
"Tom came down with a case of up-syndrome soon after meeting Caroline."
"We always thought Susie was a bit weird, but we didnt know for certain until her secret reared its ugly little head -- she was diagnosed with up-syndrome."
5:00 News Report:
"Rare condition found in man with up-syndrome... Are two penises better than one?"